Data-Driven UPLC-Orbitrap MS Analysis in Astrochemistry

Analysis of Chemical Constituents in Wuzi-Yanzong-Wan by UPLC-ESI-LTQ-Orbitrap-MS.

Wuzi-Yanzong-Wan (WZYZW), a classical traditional Chinese medicine (TCM) prescription containing Fructus Lych, Semen Cuscutae (fried), Fructus Rubi, Fructus Schisandrae chinensis (steamed) and Semen Plantaginis (fried with salt), is widely used to treat impotence, sterility, spermatorrhea, premature ejaculation, lumbago and post-micturation dribble. However, the chemical profile of WZYZW has no...

Vitamin Analysis in Food by UPLC–MS

Vitamins are defined as a biologically active group of organic compounds that have a relatively low molecular weight. They are minor, but essential for an organism’s normal health and growth. Humans need to obtain them from food or supplements [1,2]. These nutrients facilitate the metabolism of proteins, carbohydrates, and fats. They are reported to reduce damage from free radicals [3], and ins...

Data Acquisition Parameters Optimization of Quadrupole Orbitrap for Global Lipidomics on LC-MS/MS Time Frame

Multimodal Metabolomics Combining UPLC-qToF-MS and GC-MS Data in Plasma and Brain Tissue

Metabolomic analysis of biological fluids and tissues has become an increasingly routine tool in the biological toolbox. However, challenges remain to be overcome, including developing strategies to maximise coverage of the metabolome without requiring large sample volumes. Here we describe a multimodal strategy that combines data using both LC-MS and GC-MS from a unique vial with a sample of p...

Determination of cannabinoids in whole blood by UPLC-MS-MS.

An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blood. Samples were prepared by protein precipitation followed by solid-phase ext...